People at risk for anaphylaxis are always advised to keep their EpiPens at room temperature. So U.S. researchers examined whether freezing the device would impact its functionality. After freezing 104 EpiPens for 24 hours, thawing and testing performance, they found that the devices still worked correctly.
The study focused solely on EpiPens. Results should not be applied to other types of epinephrine auto-injectors, researchers cautioned. The study did not assess whether epinephrine itself degrades when frozen, but researchers cited a 2016 review which suggested that everyday temperature fluctuations, including freezing, would not significantly degrade epinephrine. The study involved just one freeze over a 24-hour period; the impact of multiple, extended freezes was not assessed.
The findings were presented at the American College of Allergy, Asthma and Immunology’s Annual Scientific Meeting.